Alzheimer’s Biomarker Researchers Suggest Caution with Dietary Supplement

A study led by University of California, San Diego (UCSD), scientists has provided new evidence to support their suggestion that elevated levels of an enzyme called phosphoglycerate dehydrogenase (PHGDH) in the blood of older adults could be an early warning sign of Alzheimer’s disease (AD). The newly reported results of the team’s analysis of human brain tissue have demonstrated a trend consistent with their previous findings from blood samples, and showed that expression levels of the gene coding for PHGDH were higher in adults with different stages of AD, even at the early stages, before cognitive symptoms manifested.

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