Promising Alzheimer’s Marker in Blood Prompts Warning About Brain-Boosting Supplements

Summary: Elevated levels of PHGDH in the blood could signal the earliest stages of Alzheimer’s disease. Researchers caution older adults against using “brain-boosting” supplements that contain serine due to its link to PHGDH. As PHGDH is a key enzyme in serine production, elevated PHGDH levels result in increased serine levels in the brain.

Source: UCSD

Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer’s disease, and a study led by the University of California San Diego provides new evidence to support this claim.

In analyzing brain tissue, researchers

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Alzheimer’s Biomarker Researchers Suggest Caution with Dietary Supplement

A study led by University of California, San Diego (UCSD), scientists has provided new evidence to support their suggestion that elevated levels of an enzyme called phosphoglycerate dehydrogenase (PHGDH) in the blood of older adults could be an early warning sign of Alzheimer’s disease (AD). The newly reported results of the team’s analysis of human brain tissue have demonstrated a trend consistent with their previous findings from blood samples, and showed that expression levels of the gene coding for PHGDH were higher in adults with different stages of AD, even at the early stages, before cognitive symptoms manifested.

The latest

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